So far, more than 70 genes involved in the chronological lifespan (CLS) of Schizosaccharomyces pombe (fission yeast) have been reported. In this mini‐review, we arrange and summarize these genes based on the reported genetic interactions between them and the physical interactions between their products. We describe the signal transduction pathways that affect CLS in S. pombe: target of rapamycin complex 1, cAMP‐dependent protein kinase, Sty1, and Pmk1 pathways have important functions in the regulation of CLS extension. Furthermore, the Php transcription complex, Ecl1 family proteins, cyclin Clg1, and the cyclin‐dependent kinase Pef1 are important for the regulation of CLS extension in S. pombe. Most of the known genes involved in CLS extension are related to these pathways and genes. In this review, we focus on the individual genes regulating CLS extension in S. pombe and discuss the interactions among them.

中文翻译：

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影响粟酒裂殖酵母（裂殖酵母）按时间顺序寿命延长的基因

到目前为止，已经报道了超过 70 个基因参与裂殖酵母（裂殖酵母）的时间顺序寿命（CLS）。在这篇小型综述中，我们根据所报告的基因之间的遗传相互作用及其产品之间的物理相互作用来排列和总结这些基因。我们描述了影响S 中CLS 的信号转导途径。pombe：雷帕霉素复合物 1 的靶标、cAMP 依赖性蛋白激酶、Sty1 和 Pmk1 通路在 CLS 延伸的调节中具有重要功能。此外，Php 转录复合物、Ecl1 家族蛋白、细胞周期蛋白 Clg1 和细胞周期蛋白依赖性激酶 Pef1 对调节S中 CLS 的延伸很重要。庞贝. 大多数已知的参与 CLS 延伸的基因都与这些途径和基因有关。在这篇综述中，我们专注于调节S 中CLS 延伸的单个基因。pombe并讨论它们之间的相互作用。