Vitamin D is an essential nutrient that has long been known to regulate skeletal growth and integrity. In models of major appendage regeneration, treatment with vitamin D analogs has been reported to improve aspects of zebrafish fin regeneration in specific disease or gene misexpression contexts, but also to disrupt pattern in regenerating salamander limbs. Recently, we reported strong mitogenic roles for vitamin D signaling in several zebrafish tissues throughout life stages, including epidermal cells and osteoblasts of adult fins. To our knowledge, molecular genetic approaches to dissect vitamin D function in appendage regeneration have not been described.

中文翻译：

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维生素 D 信号调控斑马鱼鳍再生

维生素 D 是一种必需的营养素，长期以来被认为可以调节骨骼生长和完整性。在主要附肢再生模型中，据报道用维生素 D 类似物治疗可以改善斑马鱼鳍在特定疾病或基因错误表达情况下的再生方面，但也可以破坏蝾螈肢体再生的模式。最近，我们报道了维生素 D 信号在整个生命阶段的几种斑马鱼组织中的强有丝分裂作用，包括表皮细胞和成年鳍的成骨细胞。据我们所知，尚未描述剖析附肢再生中维生素 D 功能的分子遗传学方法。