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Axolotl liver regeneration is accomplished via compensatory congestion mechanisms regulated by ERK signaling after partial hepatectomy
Developmental Dynamics ( IF 2.5 ) Pub Date : 2020-10-16 , DOI: 10.1002/dvdy.262
Ayaka Ohashi 1, 2 , Nanami Saito 1, 3 , Rena Kashimoto 1, 3 , Saya Furukawa 1, 2 , Sakiya Yamamoto 1, 2 , Akira Satoh 1
Affiliation  

Axolotls have remarkable organ-level regeneration capability. They can regenerate their limbs, tail, brain, gills, and heart. The liver had been considered to be a regenerative organ in these highly regeneration-competent animals. Therefore, no research had been performed on liver regeneration in urodele amphibians. In the present study, we focused on axolotl liver regeneration and found a unique regeneration mechanism compared with other vertebrates.

中文翻译:

蝾螈肝再生是通过部分肝切除术后 ERK 信号调节的代偿性充血机制完成的

蝾螈具有显着的器官水平再生能力。它们可以再生四肢、尾巴、大脑、鳃和心脏。在这些具有高度再生能力的动物中,肝脏被认为是一种再生器官。因此,尚未对有尾两栖动物的肝脏再生进行研究。在本研究中,我们专注于蝾螈肝脏再生,并发现与其他脊椎动物相比具有独特的再生机制。
更新日期:2020-10-16
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