Gastroesophageal reflux disease (GERD) is a condition with increasing prevalence and morbidity in the United States and worldwide. Despite advances in medical and surgical therapy over the last 30 years, gaps remain in the therapeutic profile of options. Flexible upper endoscopy offers the promise of filling in these gaps in a potentially minimally invasive approach. In this concise review, we focus on the plethora of endoluminal therapies available for the treatment of GERD. Therapies discussed include injectable agents, electrical stimulation of the lower esophageal sphincter, antireflux mucosectomy, radiofrequency ablation, and endoscopic suturing devices designed to create a fundoplication. As new endoscopic treatments become available, we come closer to the promise of the incisionless treatment of GERD. The known data surrounding the indications, benefits, and risks of these historical, current, and emerging approaches are reviewed in detail.

中文翻译：

---

GERD的内窥镜治疗

胃食管反流病 (GERD) 是一种在美国和世界范围内患病率和发病率不断增加的疾病。尽管过去 30 年来内科和外科治疗取得了进展，但在治疗方案方面仍然存在差距。灵活的上消化道内窥镜有望以一种潜在的微创方法填补这些空白。在这篇简明的综述中，我们重点介绍了大量可用于治疗 GERD 的腔内疗法。讨论的疗法包括注射剂、食管下括约肌电刺激、抗反流黏膜切除术、射频消融术和旨在创建胃底折叠术的内窥镜缝合装置。随着新的内窥镜治疗的出现，我们更接近于 GERD 无切口治疗的承诺。