Recent malaria vaccine trials in endemic areas have yielded disparate results compared to studies conducted in non-endemic areas. A workshop was organized to discuss the differential pre-erythrocytic stage malaria vaccine (Pre-E-Vac) efficacies and underlying protective immunity under various conditions. It was concluded that many factors, including vaccine technology platforms, host genetics or physiologic conditions, and parasite and mosquito vector variations, may all contribute to Pre-E-Vac efficacy. Cross-disciplinary approaches are needed to decipher the multi-dimensional variables that contribute to the observed vaccine hypo-responsiveness. The malaria vaccine community has an opportunity to leverage recent advances in immunology, systems vaccinology, and high dimensionality data science methodologies to generate new clinical datasets with unprecedented levels of functional resolution as well as capitalize on existing datasets for comprehensive and aggregate analyses. These approaches would help to unlock our understanding of Pre-E-Vac immunology and to translate new candidates from the laboratory to the field more predictably.

与在非流行地区进行的研究相比，最近在流行地区进行的疟疾疫苗试验产生了截然不同的结果。举办了一个研讨会，讨论在不同条件下红细胞前期疟疾疫苗（Pre-E-Vac）的不同功效和潜在的保护性免疫。结论是，许多因素，包括疫苗技术平台，宿主遗传学或生理条件，以及寄生虫和蚊媒的变异，都可能对Pre-E-Vac的功效有影响。需要跨学科的方法来解释有助于观察到的疫苗低反应性的多维变量。疟疾疫苗界有机会利用免疫学，系统疫苗学，以及高维数据科学方法，以生成具有空前水平的功能分辨率的新临床数据集，并利用现有数据集进行全面和汇总分析。这些方法将有助于解锁我们对Pre-E-Vac免疫学的理解，并更可预测地将新候选人从实验室转移到现场。