Cotarnine is an important organic molecule having tetrahydroisoquinoline core. Cotarnine core exhibits very important biological property. Its biological property changes by correct functionalization of core structure to form new molecules. Herein we describe the developments of chemistry of cotarnine and its derivatives in terms of property, synthesis, reactivity and biological application from scratch to complex core. This review will update the information about cotarnine chemistry and its application for synthesis of different bioactive product.

中文翻译：

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烟碱及其类似物的化学和生物学应用进展

肾上腺素是具有四氢异喹啉核心的重要有机分子。肾上腺素核心表现出非常重要的生物学特性。核心结构的正确功能化会形成新分子，从而改变其生物学特性。在本文中，我们从性质，合成，反应性以及从头到复杂核的生物学应用方面描述了卡塔宁及其衍生物的化学发展。这篇评论将更新有关烟碱化学及其在合成不同生物活性产品中的应用的信息。