Gene expression comprises a diverse array of enzymes, proteins, non-coding transcripts, and cellular structures to guide the transfer of genetic information to its various final products. In the brain, the coordination among genes, or lack thereof, characterizes individual brain regions, mediates a variety of brain-related disorders, and brings light to fundamental differences between species. RNA processing, occurring between transcription and translation, controls an essential portion of gene expression through splicing, editing, localization, stability, and interference. The machinery to regulate transcripts must operate with precision serving as a blueprint for proteins and non-coding RNAs to derive their identity. Therefore, RNA processing has a broad scope of influence in the brain, as it modulates cell morphogenesis during development and underlies mechanisms behind certain neurological diseases. Here, we present these ideas through recent findings on RNA processing in development and post-developmental maturity to advance therapeutic discoveries and the collective knowledge of the RNA life cycle.

基因表达包括各种酶、蛋白质、非编码转录物和细胞结构，以指导遗传信息向其各种最终产物的转移。在大脑中，基因之间的协调或缺乏协调是个体大脑区域的特征，介导了各种与大脑相关的疾病，并揭示了物种之间的根本差异。RNA 加工发生在转录和翻译之间，通过剪接、编辑、定位、稳定性和干扰控制基因表达的重要部分。调节转录本的机器必须精确运行，作为蛋白质和非编码 RNA 获得其身份的蓝图。因此，RNA加工在大脑中具有广泛的影响，因为它在发育过程中调节细胞形态发生，并构成某些神经系统疾病背后的机制。在这里，我们通过最近关于发育中的 RNA 加工和发育后成熟度的发现来提出这些想法，以推进治疗发现和 RNA 生命周期的集体知识。