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Swimming exercise during morphine abstinence in parents-to-be attenuated morphine-induced conditioned place preference and locomotor sensitization only in male rat offspring
Neuroscience Letters ( IF 2.5 ) Pub Date : 2020-10-17 , DOI: 10.1016/j.neulet.2020.135433
Mona Taghipour , Parviz Sabahi , Alireza pooriamehr , Hossein Miladi-Gorji

This study was designed to examine the effects of swimming exercise during morphine abstinence in parents-to-be before mating on morphine-induced conditioned place preference (CPP) and locomotor sensitization in the pubertal male and female rat offspring. Male and female Wistar rats were injected with bi-daily doses (10 mg/kg, 12 h intervals) of morphine for 14 days. The exercising rats exposed to a regular swimming exercise (45 min/d, five days per a week) during 30 days of morphine abstinence before mating. Then, the pubertal male and female rat offspring were tested for morphine-induced CPP and locomotor sensitization (using the open field). The results showed that the pubertal male offspring of the morphine-abstinent parents-to-be exhibited an increase in CPP to morphine and locomotor activity after morphine challenge than the offspring from the control group. While, swimming exercise in morphine-abstinent parents-to-be decreased CPP score and locomotor activity in the pubertal male offspring than control offspring. Thus, exposure to swimming exercise in morphine-abstinent parents-to-be before mating may exert a protective effect against morphine-induced reward and locomotor sensitization in their pubertal offspring which may prevent the vulnerability of the first generation to drug abuse following opiate-addicted parents before mating.



中文翻译:

仅在雄性大鼠后代中,在拟禁欲的父母体内吗啡戒断期间进行的游泳运动减弱了吗啡引起的条件性位置偏爱和运动敏化

这项研究旨在研究吗啡禁欲期间父母在进行吗啡游泳之前进行游泳运动对青春期雄性和雌性大鼠后代中吗啡诱导的条件性位置偏爱(CPP)和运动敏化的影响。雄性和雌性Wistar大鼠每天两次注射吗啡(10 mg / kg,间隔12小时),持续14天。运动的大鼠在交配前的30天吗啡戒断期间要进行常规游泳锻炼(45分钟/天,每周5天)。然后,对青春期的雄性和雌性大鼠后代进行吗啡诱导的CPP和运动敏化测试(使用开放视野)。结果显示,与对照组相比,吗啡戒断父母的青春期雄性后代在吗啡攻击后的CPP对吗啡和运动活性的升高。而在吗啡戒断父母中游泳运动会降低青春期雄性后代的CPP评分和运动能力。因此,在交配前要戒绝吗啡的父母进行游泳运动可能会对吗啡诱导的青春期后代的奖励和运动敏化产生保护作用,这可能会阻止阿片成瘾后第一代对药物滥用的脆弱性。父母交配前。在绝经吗啡的父母中进行游泳运动比对照后代降低了青春期雄性后代的CPP评分和运动能力。因此,在交配前戒绝吗啡的父母游泳锻炼可能对其青春期后代产生吗啡诱导的奖赏和运动敏化的保护作用,这可能防止第一代鸦片瘾后易受药物滥用的影响。父母交配前。在绝经吗啡的父母中进行游泳运动比对照后代降低了青春期雄性后代的CPP评分和运动能力。因此,在交配前要戒绝吗啡的父母进行游泳运动可能会对吗啡诱导的青春期后代的奖励和运动敏化产生保护作用,这可能会阻止阿片成瘾后第一代对药物滥用的脆弱性。父母交配前。

更新日期:2020-10-29
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