The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an international public health emergency. Although respiratory symptoms predominate the clinical manifestations of COVID-19, gastrointestinal symptoms have been observed in a subset of patients. Notably, some patients have nausea/vomiting as the first clinical manifestation of COVID-19, which is often overlooked by people. It is now clear that not only the lungs, the gastrointestinal tract could also be attacked by SARS-CoV-2. Its host receptor angiotensin-converting enzyme 2 (ACE2), which acts as a gateway to infection, has been found to be highly expressed in the gastrointestinal epithelium and may lead to the development of nausea/vomiting. Raise awareness of these symptoms and take timely intervention would help people combat the pandemic. This review discussed epidemiology, mechanisms, management, and prevention of COVID-19 related nausea and vomiting.

由严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 大流行是国际突发公共卫生事件。尽管呼吸道症状在 COVID-19 的临床表现中占主导地位，但在一部分患者中观察到了胃肠道症状。值得注意的是，一些患者以恶心/呕吐为 COVID-19 的第一个临床表现，这往往被人们所忽视。现在很明显，不仅肺部，胃肠道也可能受到 SARS-CoV-2 的攻击。已发现其宿主受体血管紧张素转换酶 2 (ACE2) 作为感染的途径，在胃肠道上皮中高度表达，并可能导致恶心/呕吐的发生。提高对这些症状的认识并及时采取干预措施将有助于人们抗击大流行。本综述讨论了 COVID-19 相关恶心和呕吐的流行病学、机制、管理和预防。