当前位置: X-MOL 学术Environ. Toxicol. Pharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Genotoxic effects of glyphosate on Physalaemus tadpoles
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-10-17 , DOI: 10.1016/j.etap.2020.103516
Jéssica Samara Herek , Luana Vargas , Suélen Andressa Rinas Trindade , Camila Fatima Rutkoski , Natani Macagnan , Paulo Afonso Hartmann , Marilia Teresinha Hartmann

Genotoxicity studies have revealed that pesticides bind to genetic material in non-target vertebrates, thereby impairing the genetic integrity of these animals. The main objective of this study was to determine the genotoxic damage in erythrocytes of two native South American amphibian Physalaemus cuvieri and Physalaemus gracilis, both species exposed to a glyphosate-based herbicide. We evaluated the presence of micronuclei (MN) and erythrocyte nuclear abnormalities (ENA) as biomarkers for potential genotoxic compounds. Tadpoles were exposed to doses permitted by Brazilian legislation and concentrations found naturally in Brazilian and Argentinian waters (500, 700 and 1000 μg/L). Glyphosate-based herbicide caused micronuclei formation and several types of erythrocyte nuclear abnormalities in both Physalaemus species. The total frequency of MN and ENA demonstrated the occurrence of cell damage at all tested concentrations. Glyphosate herbicide can be considered a genotoxic that may impact the genetic integrity of native populations of P. cuvieri and P. gracilis.



中文翻译:

草甘膦对遗传毒性Physalaemus蝌蚪

基因毒性研究表明,农药会与非目标脊椎动物的遗传物质结合,从而损害这些动物的遗传完整性。这项研究的主要目的是确定南美洲两栖两栖类Physalaemus cuvieriPhysalaemus gracilis对红细胞的遗传毒性损害,这两种物种都暴露于基于草甘膦的除草剂。我们评估了微核(MN)和红细胞核异常(ENA)的存在作为潜在遗传毒性化合物的生物标记。were暴露于巴西法律允许的剂量和巴西和阿根廷水域中自然存在的浓度(500、700和1000μg/ L)。基于草甘膦的除草剂导致两种物种中的微核形成和几种类型的红细胞核异常。MN和ENA的总频率表明在所有测试浓度下都发生了细胞损伤。草甘膦除草剂可被认为具有遗传毒性,可能会影响库疟原虫粉虱的原生种群的遗传完整性。

更新日期:2020-10-30
down
wechat
bug