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Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity
Doklady Chemistry ( IF 0.8 ) Pub Date : 2020-06-01 , DOI: 10.1134/s0012500820360021
I. S. Odin , S. Cao , D. Hughes , E. V. Zamaratskii , Yu. P. Zarubin , P. P. Purygin , A. A. Golovanov , S. S. Zlotskii

Previously unknown N-acyl derivatives of 1,2,3-triazole chalcones have been prepared by the acylation of the potassium salts of 4-(3-oxo-3-phenylprop-1-en-1-yl)-5-phenyl-1,2,3-triazolides with carboxylic acid chlorides. The introduction of the N-acyl residue into the heterocyclic moiety of 1-aryl-3-(1H-1,2,3-triazol-4-yl)prop-2-en-1-ones has been shown to afford compounds with antibacterial activity.

中文翻译:

新型N-酰基-1,2,3-三唑查耳酮的合成及抗菌活性测定

以前未知的 1,2,3-三唑查尔酮的 N-酰基衍生物已通过 4-(3-oxo-3-phenylprop-1-en-1-yl)-5-phenyl- 的钾盐酰化制备1,2,3-三唑化物与羧酸氯化物。将 N-酰基残基引入 1-芳基-3-(1H-1,2,3-三唑-4-基)prop-2-en-1-ones 的杂环部分已被证明可以提供具有以下特征的化合物抗菌活性。
更新日期:2020-06-01
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