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Kinetic factors may reshape the dependence of crystal nucleation rate on temperature in protein bulk solution
Journal of Biological Physics ( IF 1.8 ) Pub Date : 2020-10-16 , DOI: 10.1007/s10867-020-09558-1
Ivaylo L Dimitrov 1
Affiliation  

Here we provide an analysis of primary results obtained from a study of apoferritin crystal nucleation in compositionally invariant bulk solution at constant supersaturation ratio of the protein. The temperature dependence of the stationary crystal nucleation rate in the protein bulk solution is obtained with the help of experimentally determined probability for detection of at least one crystal per solution volume until a given time. The stationary crystal nucleation rate demonstrates unusual behavior with temperature. We emphasize that this is caused by kinetic factors that are often disregarded in the frame of the classical nucleation theory but can certainly affect the nucleation kinetics.

中文翻译:

动力学因素可能会重塑蛋白质本体溶液中晶体成核速率对温度的依赖性

在这里,我们提供了对在蛋白质的恒定过饱和比下组成不变的本体溶液中脱铁铁蛋白晶体成核研究获得的主要结果的分析。蛋白质本体溶液中稳定晶体成核速率的温度依赖性是在实验确定的概率的帮助下获得的,该概率在给定时间之前每个溶液体积检测至少一个晶体。稳定的晶体成核率表现出不寻常的温度行为。我们强调这是由动力学因素引起的,这些因素在经典成核理论的框架中经常被忽视,但肯定会影响成核动力学。
更新日期:2020-10-16
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