Bismuth compounds are known for their activity against multiple microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain poorly explored. The objective of this work is to further the research of BiNPs for nanomedicine-related applications. Stable Polyvinylpyrrolidone (PVP)-coated BiNPs were produced by a chemical reduction process, in less than 30 min. We produced stable, small, spheroid PVP-coated BiNPs with a crystalline organization. The PVP-BiNPs showed potent antibacterial activity against the pathogenic bacterium Staphylococcus aureus and antifungal activity against the opportunistic pathogenic yeast Candida albicans, both under planktonic and biofilm growing conditions. Our results indicate that BiNPs represent promising antimicrobial nanomaterials, and this facile synthetic method may allow for further investigation of their activity against a variety of pathogenic microorganisms.

中文翻译：

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通过简便合成方法获得的铋纳米粒子对金黄色葡萄球菌和白色念珠菌具有抗菌活性

铋化合物以其对多种微生物的活性而闻名。然而，铋纳米粒子（BiNPs）的抗生素特性仍然缺乏探索。这项工作的目的是进一步研究用于纳米医学相关应用的 BiNPs。稳定的聚乙烯吡咯烷酮 (PVP) 涂层 BiNPs 是通过化学还原工艺在不到 30 分钟内生产的。我们生产了具有结晶组织的稳定、小型、球形 PVP 涂层 BiNP。PVP-BiNPs 在浮游和生物膜生长条件下均显示出对致病菌金黄色葡萄球菌的有效抗菌活性和对机会致病性酵母白色念珠菌的抗真菌活性。我们的结果表明，BiNPs 代表了有前途的抗菌纳米材料，