The COVID19 pandemic has resulted in 1,092,342 deaths as of 14th October 2020, indicating the urgent need for a vaccine. This study highlights novel protein sequences generated by shot gun sequencing protocols that could serve as potential antigens in the development of novel subunit vaccines and through a stringent inclusion criterion, we characterized these protein sequences and predicted their 3D structures. We found distinctly antigenic sequences from the SARS-CoV-2 that have led to identification of 4 proteins that demonstrate an advantageous binding with Human leukocyte antigen-1 molecules. Results show how previously unexplored proteins may serve as better candidates for subunit vaccine development due to their high stability and immunogenicity, reinforce by their HLA-1 binding propensities and low global binding energies. This study thus takes a unique approach towards furthering the development of vaccines by employing multiple consensus strategies involved in immuno-informatics technique.

中文翻译：

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COVID19：探索罕见的表位，通过MHC1结合产生稳定的免疫反应

截至2020年10月14日，COVID19大流行已经导致1,092,342人死亡，这表明迫切需要疫苗。这项研究重点介绍了由shot弹枪测序方案产生的新型蛋白质序列，这些序列可作为新型亚基疫苗开发中的潜在抗原，并通过严格的纳入标准，我们对这些蛋白质序列进行了表征并预测了其3D结构。我们从SARS-CoV-2中发现了明显的抗原序列，该序列已导致鉴定出4种蛋白质，这些蛋白质表现出与人白细胞抗原-1分子的有利结合。结果显示，以前未开发的蛋白质由于其高稳定性和免疫原性，通过其HLA-1结合倾向和较低的整体结合能而得以增强，因此可以更好地用作亚单位疫苗开发的候选物。