Deactivation of primed SARS-CoV-2 prior to cell entry constitutes an emergency brake in COVID-19 infection if vaccine-induced antibodies fail to block recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor. The timing and locus for the therapeutic intervention are dictated by the cell entry mechanism and by the selective advantage of the dominant D614G mutation.

中文翻译：

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消除 SARS-CoV-2：疫苗失败情况下的紧急刹车

如果疫苗诱导的抗体不能阻止对人血管紧张素转换酶 2 (hACE2) 受体的识别，则在细胞进入之前灭活已引发的 SARS-CoV-2 会构成 COVID-19 感染的紧急刹车。治疗干预的时间和地点由细胞进入机制和显性 D614G 突变的选择性优势决定。