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Natural Plant Products: A Less Focused Aspect for the COVID-19 Viral Outbreak
Frontiers in Plant Science ( IF 5.6 ) Pub Date : 2020-08-18 , DOI: 10.3389/fpls.2020.568890
Anamika Pandey , Mohd Kamran Khan , Mehmet Hamurcu , Sait Gezgin

The sudden emergence of COVID-19 caused by a novel coronavirus (nCoV) led the entire world to search for relevant solutions to fight the pandemic. Although continuous trials are being conducted to develop precise vaccines and therapeutic antibodies, a potential remedy is yet to be developed. Plants have largely contributed to the treatment of several human diseases and different phytoconstituents have been previously described to impede the replication of numerous viruses. Despite the previous positive reports of plant-based medications, no successful clinical trials of phyto-anti-COVID drugs could be conducted to date. In this article, we discuss varying perspectives on why phyto-anti-viral drug clinical trials were not successful in the case of COVID-19. The issue has been discussed in light of the usage of plant-based therapeutics in previous coronavirus outbreaks. Through this article, we aim to identify the disadvantages in this research area and suggest some measures to ensure that phytoconstituents can efficiently contribute to future random viral outbreaks. It is emphasized that if used strategically phyto-inhibitors with pre-established clinical data for other diseases can save the time required for long clinical trials. The scientific community should competently tap into phytoconstituents and take their research up to the final stage of clinical trials so that potential phyto-anti-COVID drugs can be developed.



中文翻译:

天然植物产品:COVID-19病毒爆发的关注点较少

由新型冠状病毒(nCoV)引起的COVID-19的突然出现导致整个世界都在寻找与大流行作斗争的解决方案。尽管正在进行连续试验以开发精确的疫苗和治疗性抗体,但尚未开发出潜在的补救方法。植物在很大程度上治疗了几种人类疾病,并且先前已经描述了不同的植物成分会阻碍多种病毒的复制。尽管先前有基于植物的药物的积极报道,但迄今为止尚无法成功进行植物抗COVID药物的临床试验。在本文中,我们讨论了关于在COVID-19情况下植物抗病毒药物临床试验为何不成功的不同观点。鉴于先前的冠状病毒爆发中基于植物的治疗方法的使用,已经对该问题进行了讨论。通过本文,我们旨在确定该研究领域的弊端,并提出一些措施,以确保植物成分可以有效地促进未来的随机病毒爆发。要强调的是,如果将具有战略意义的植物抑制剂与其他疾病的预先建立的临床数据一起使用,可以节省长时间临床试验所需的时间。科学界应充分利用植物成分,并将其研究进展到临床试验的最后阶段,以便开发出潜在的植物抗COVID药物。我们旨在确定该研究领域的劣势,并提出一些措施,以确保植物成分可以有效地促进未来的随机病毒爆发。要强调的是,如果将具有战略意义的植物抑制剂与其他疾病的预先建立的临床数据一起使用,可以节省长时间临床试验所需的时间。科学界应充分利用植物成分,并将其研究进展到临床试验的最后阶段,以便开发出潜在的植物抗COVID药物。我们旨在确定该研究领域的劣势,并提出一些措施,以确保植物成分可以有效地促进未来的随机病毒爆发。要强调的是,如果将具有战略意义的植物抑制剂与其他疾病的预先建立的临床数据一起使用,可以节省长时间临床试验所需的时间。科学界应充分利用植物成分,并将其研究进展到临床试验的最后阶段,以便开发出潜在的植物抗COVID药物。

更新日期:2020-10-16
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