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In Vitro Evaluation of a Vibrating-Mesh Nebulizer Repeatedly Use over 28 Days
Pharmaceutics ( IF 5.4 ) Pub Date : 2020-10-15 , DOI: 10.3390/pharmaceutics12100971
Hui-Ling Lin , Chi-Shuo Chen , James B. Fink , Guo-Hao Lee , Chun-Wei Huang , Jui-Chi Chen , Zi Yi Chiang

This in vitro study evaluates the performance of a disposable vibrating-mesh nebulizer when used for 28 days. A lung model was used to simulate the breathing pattern of an adult with chronic obstructive pulmonary disease. The vibrating-mesh nebulizer was used for three treatments/day over 28 days without cleaning after each test. Results showed that the inhaled drug dose was similar during four weeks of use (p = 0.157), with 16.73 ± 4.46% at baseline and 15.29 ± 2.45%, 16.21 ± 2.21%, 17.56 ± 1.98%, and 17.13 ± 1.81%, after the first, second, third, and fourth weeks, respectively. The particle size distribution, residual drug volume, and nebulization time remained similar across four weeks of use (p = 0.110, p = 0.763, and p = 0.573, respectively). Mesh was inspected using optical microscopy and showed that approximately 50% of mesh pores were obscured after 84 runs, and light penetration through the aperture plate was significantly reduced after the 21st use (p < 0.001) with no correlation to nebulizer performance. We conclude that the vibrating-mesh nebulizer delivered doses of salbutamol solution effectively over four weeks without cleaning after each use even though the patency and clarity of the aperture plate were reduced by the first week of use.

中文翻译:

28天重复使用的振动筛雾化器的体外评估

这项体外研究评估了使用了28天的一次性振动筛网雾化器的性能。肺部模型用于模拟患有慢性阻塞性肺病的成年人的呼吸模式。振动筛雾化器在每天28天的时间内每天进行3次处理,无需每次清洁。结果表明,在使用4周后吸入药物的剂量相似(p = 0.157),基线后分别为16.73±4.46%和15.29±2.45%,16.21±2.21%,17.56±1.98%和17.13±1.81%第一,第二,第三和第四周。在使用四周后,粒径分布,残留药物量和雾化时间保持相似(p = 0.110,p = 0.763和p分别为0.573)。使用光学显微镜检查了网孔,结果表明在84次运行后约有50%的网孔被遮盖了,在第21次使用后,穿过孔板的光穿透率显着降低(p <0.001),与雾化器性能无关。我们得出的结论是,即使在使用的第一周内孔板的通畅性和清晰度降低,振动筛雾化器仍可在四周内有效地递送剂量的沙丁胺醇溶液,而无需每次清洁。
更新日期:2020-10-16
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