Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.

中文翻译：

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磷脂酶活性，免疫细胞功能和动脉粥样硬化的界面

磷脂酶是一种脂质改变酶，可以降低或增加生物活性脂质水平。具有生物活性的脂质引发信号传导反应，激活转录因子，促进G偶联蛋白活性，并调节膜流动性，介导细胞功能。磷脂酶和它们产生的生物活性脂质是免疫细胞活性的重要调节剂，指示促炎和促分辨活性。在动脉粥样硬化期间，促炎症和促分辨活动分别控制着动脉粥样硬化的进展和消退。这篇综述将研究磷脂酶活性，免疫细胞功能和动脉粥样硬化的界面。