Purpose

Rare genetic conditions like Down syndrome (DS) are historically understudied. Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is unknown how the COVID-19 pandemic affects individuals with DS. Herein, we report an analysis of individuals with DS who were hospitalized with COVID-19 in New York, New York, USA.

Methods

In this retrospective, dual-center study of 7246 patients hospitalized with COVID-19, we analyzed all patients with DS admitted in the Mount Sinai Health System and Columbia University Irving Medical Center. We assessed hospitalization rates, clinical characteristics, and outcomes.

Results

We identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis and mechanical ventilation.

Conclusion

We demonstrate that individuals with DS who are hospitalized with COVID-19 are younger than their non-DS counterparts, and that they have more severe disease than age-matched controls. We conclude that particular care should be considered for both the prevention and treatment of COVID-19 in these patients.

中文翻译：

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因 COVID-19 住院的唐氏综合症患者病情更严重

目的

历史上对唐氏综合症 (DS) 等罕见遗传疾病的研究不足。感染与心脏异常一起是 DS 患者死亡的主要原因。目前，尚不清楚 COVID-19 大流行如何影响 DS 患者。在此，我们报告了对美国纽约州纽约市因 COVID-19 住院的 DS 患者的分析。

方法

在这项针对 7246 名 COVID-19 住院患者的回顾性双中心研究中，我们分析了西奈山卫生系统和哥伦比亚大学欧文医学中心收治的所有 DS 患者。我们评估了住院率、临床特征和结局。

结果

我们确定了 12 名 DS 患者。患有 DS 的住院患者平均比没有 DS 的患者年轻 10 岁。DS 患者的疾病比对照组更严重，尤其是脓毒症和机械通​​气的发生率增加。

结论

我们证明，因 COVID-19 住院的 DS 患者比非 DS 患者年轻，并且他们的疾病比年龄匹配的对照组更严重。我们得出结论，对于这些患者的 COVID-19 预防和治疗，应考虑特别护理。