The application of optical methods for tissue diagnosis, activation, and treatment suffers dramatically from the low accessible depths due to strong light scattering in tissues. Here we demonstrate a method to address this issue by utilizing transient ultrasound waves, travelling transversally to the light propagation direction, to guide light into deeper tissue regions. We study the formation of the ultrasound-induced refractive index structures and waveguides using simple ultrasound field configurations and analyze their effects on the propagation of short light pulses. As a proof of concept, we demonstrate using 5 ns pulses of 532 nm light and Intralipid-20%-based phantoms with \(\mu _{\mathrm{s}}^\prime\) up to 4.5 cm⁻¹ a waveguide supported light intensity increase up to the depths of at least 90 mean free paths.

由于组织中强烈的光散射，光学方法在组织诊断，激活和治疗中的应用遭受了深度低的困扰。在这里，我们演示了一种方法，该方法通过利用瞬态超声波（横向于光传播方向传播）将光导入更深的组织区域来解决此问题。我们使用简单的超声场配置研究了超声诱导的折射率结构和波导的形成，并分析了它们对短光脉冲传播的影响。作为概念证明，我们演示了使用5 ns的532 nm光脉冲和基于脂质体20％的幻像，并使用长达4.5 cm ^-1的\（\ mu _ {\ mathrm {s}} ^ \ prime \ 波导支持的光强度增加到至少90个平均自由程的深度。