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Acute toxicity and health effect of perfluoroisobutyronitrile on mice: a promising substitute gas-insulating medium to SF6
Journal of Environmental Science and Health, Part A ( IF 2.1 ) Pub Date : 2020-10-15 , DOI: 10.1080/10934529.2020.1830654
Xiaoxing Zhang 1, 2 , Fanchao Ye 1 , Yi Li 1 , Shuangshuang Tian 2 , Baojuan Xie 3 , Yadong Gao 3 , Song Xiao 1
Affiliation  

Abstract

Perfluoroisobutyronitrile (C4F7N) is a new eco-friendly gas insulation medium that has potential to replace the most greenhouse gas sulfur hexafluoride (SF6) used in power industry. In order to ensure the engineering application safety, an in-depth assessment of the acute inhalation toxicity of C4F7N gas mixture is required. This article revealed gender differences in male and female mice after exposure to C4F7N and the physiological recovery characteristics of surviving mice by means of 4 h acute inhalation toxicity tests, hematological determinations and histopathological examination. Comparative analysis on the toxicity of C4F7N on mice and rats is also evaluated. We find that the LC50 of C4F7N for male and female mice is 1175 ppm (4 h), 1380 ppm (4 h) and female ones are more tolerant to C4F7N. Mice that exposed to 1000 ppm C4F7N for 4 h could survive and return to their normal state after the 14-day observation period without irreversible damage. The toxic effect duration of C4F7N on rats is longer than that of mice. Relevant results revealed the acute inhalation toxicity of C4F7N systematically and provided fundamental reference for inhalation safety protection and engineering application.



中文翻译:

全氟异丁腈对小鼠的急性毒性和健康影响:一种有希望的SF6替代气体绝缘介质

摘要

全氟异丁腈(C 4 F 7 N)是一种新型的环保型气体绝缘介质,有潜力替代电力工业中使用的最多的温室气体六氟化硫(SF 6)。为了确保工程应用安全,需要对C 4 F 7 N气体混合物的急性吸入毒性进行深入评估。本文通过4 h急性吸入毒性试验,血液学测定和组织病理学检查,揭示了暴露于C 4 F 7 N后的雄性和雌性小鼠的性别差异以及存活小鼠的生理恢复特征。C 4 F毒性的比较分析7上小鼠和大鼠N也进行评价。我们发现,雄性和雌性小鼠的C 4 F 7 N的LC 50为1175 ppm(4 h),1380 ppm(4 h),而雌性小鼠对C 4 F 7 N的耐受性更高。暴露于1000 ppm的小鼠在14天的观察期后,C 4 F 7 N可以存活4小时并恢复到正常状态,而不会受到不可逆的损害。C 4 F 7 N对大鼠的毒性作用持续时间长于小鼠。相关结果表明,C 4 F 7具有急性吸入毒性。N系统地为吸入安全防护和工程应用提供了基础参考。

更新日期:2020-10-15
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