当前位置: X-MOL 学术Mol. Cryst. Liq. Cryst. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity
Molecular Crystals and Liquid Crystals ( IF 0.7 ) Pub Date : 2020-07-23 , DOI: 10.1080/15421406.2020.1743441
Keita Tanita 1 , Yoshitaka Koseki 1 , Kazue Shimizu 2 , Hirohito Umezawa 2 , Hitoshi Kasai 1
Affiliation  

Abstract Nano-prodrug is a nanomedicine developed by the reprecipitation method, which allows nanoparticles to be fabricated by only prodrug molecules without using any nanocarriers. In the present study, we synthesized a heterodimer, composed of hinokitiol and podophyllotoxin (PPT) linked via different linkers of carbon chain length as new prodrug compounds, and fabricated their nano-prodrugs. We found that the longer the carbon chain linker, the smaller the size of nanoparticles, and the lower their cytotoxicity. We concluded that heterodimeric prodrugs can be fabricated into nano-prodrugs without reducing their drug loading capacity, and might eventually serve as a promising template for the development of novel nanomedicine.

中文翻译:

具有高载药量的桧醇改性鬼臼毒素纳米前药的制备

摘要 纳米前药是一种通过再沉淀法开发的纳米药物,它允许仅由前药分子制备纳米颗粒,而无需使用任何纳米载体。在本研究中,我们合成了一种异二聚体,由通过碳链长度不同的接头连接的桧醇和鬼臼毒素(PPT)组成,作为新的前药化合物,并制备了它们的纳米前药。我们发现碳链接头越长,纳米颗粒的尺寸越小,它们的细胞毒性越低。我们得出结论,异二聚体前药可以在不降低其载药量的情况下制成纳米前药,最终可能成为开发新型纳米药物的有前途的模板。
更新日期:2020-07-23
down
wechat
bug