ABSTRACT

One of the leading causes of death in the intensive care unit (ICU) is sepsis. Different studies have been performed on different markers to determine the cause of sepsis. microRNAs (miRNAs) are non-coding RNAs that can be released both inside and outside the cell and regulate the target gene expression by binding to the 3ʹ untranslated region (3ʹUTR) of the target genes. TLRs play an important role in innate immunity that can be modulated by biological markers such as microRNAs. In this study, we summarized the recent progress on the role of extracellular and intracellular microRNAs in sepsis. It has also been focused on the association of TLRs with extracellular and intracellular micro RNAs in the regulation of sepsis. In conclusion, this study has provided new insight into the role of microRNAs as a regulator of the TLRs which may lead to the aberrant inflammatory response in sepsis. Therefore, it suggests that both intracellular and extracellular microRNAs may play a therapeutic role in the treatment of sepsis via regulating TLRs. However, yet sepsis and septic shock are medical emergencies and further studies are needed to specify the exact role of microRNAs and TLRs in sepsis.

摘要

重症监护病房 (ICU) 中死亡的主要原因之一是败血症。已经对不同的标志物进行了不同的研究以确定败血症的原因。microRNAs（miRNAs）是非编码RNA，可以在细胞内外释放，通过与靶基因的3′非翻译区（3′UTR）结合来调节靶基因的表达。TLR 在先天免疫中发挥重要作用，可以通过 microRNA 等生物标志物进行调节。在本研究中，我们总结了细胞外和细胞内 microRNA 在脓毒症中作用的最新进展。它还专注于 TLR 与细胞外和细胞内 micro RNA 在脓毒症调节中的关联。综上所述，这项研究为 microRNA 作为 TLR 调节剂的作用提供了新的见解，这可能导致脓毒症中的异常炎症反应。因此，这表明细胞内和细胞外的 microRNA 都可能通过调节 TLR 在脓毒症的治疗中发挥治疗作用。然而，脓毒症和脓毒性休克是医疗紧急情况，需要进一步研究来明确 microRNA 和 TLR 在脓毒症中的确切作用。