Peptide‐functionalized nanoparticles combine the best of both; the ability of nanoparticles to deliver a drug “cargo” throughout the body and the ability of peptides to selectively target certain cell types or biological systems. The vast majority of peptide‐functionalized nanoparticles employ only one type of peptide, however, to truly realize the potential of these systems in medicine, nanoparticles equipped with two or even more peptide functionalities are desirable. In this review, the latest developments in dual‐peptide functionalized nanoparticles are discussed. These are categorized depending on their structure; first broadly into grafted and self‐assembled dual‐peptide‐nanoparticles with the former then subdivided further into nonconjugated, linearly conjugated and branched conjugated dual‐peptide functionalized nanoparticles. These different categories of dual‐peptide nanoparticles are then discussed with regards to the type of functional peptides used and their role in selective targeting nanomedicine.

中文翻译：

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用于治疗用途的双肽功能化纳米颗粒

肽官能化的纳米颗粒结合了两者的优点。纳米颗粒在体内传递药物“货物”的能力以及肽选择性靶向某些细胞类型或生物系统的能力。绝大多数肽官能化的纳米颗粒仅使用一种类型的肽，但是，要真正实现这些系统在医学中的潜力，需要具有两种或更多种肽功能的纳米颗粒。在这篇综述中，讨论了双肽功能化纳米颗粒的最新发展。这些根据其结构进行分类。首先将其大致分为接枝和自组装的双肽纳米颗粒，然后再细分为非共轭，线性共轭和支链共轭双肽功能化纳米颗粒。