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Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats
Environmental Toxicology ( IF 4.5 ) Pub Date : 2020-10-15 , DOI: 10.1002/tox.23043
Ling‐Ling Zhao 1 , Emmanuel Ayobami Makinde 2 , Opeyemi Joshua Olatunji 2
Affiliation  

Diabetic mellitus is a chronic metabolic disorder that is associated with several complications including testicular dysfunction. This research investigated the protective action of the ethyl acetate extract from Shorea roxburghii (SRE) on diabetes induced testicular damage in rats. Diabetic rats were orally administered with SRE at doses of 100 and 400 mg/kg for 4 weeks. SRE improved the body weight gain, testes weight, testes index and increased serum concentration of testosterone. Furthermore, SRE increased the testicular antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase. In addition, SRE ameliorated testicular inflammatory mediators such as myeloperoxidase, tumor necrosis factor alpha, interleukin 6, p38 MAPK and nuclear factor kappa B activation and decreased testicular cell apoptosis in the treated diabetic rats. SRE also raised sperm parameters after treatment of diabetic rats. Conclusively, our results suggested that SRE ameliorated diabetes induced testicular damage by inhibiting oxidative stress and inflammation.

中文翻译:

蜀葵乙酸乙酯提取物对糖尿病大鼠睾丸损伤的保护作用

糖尿病是一种慢性代谢紊乱,与包括睾丸功能障碍在内的多种并发症有关。本研究调查了刺梨 (SRE) 乙酸乙酯提取物对糖尿病诱导的大鼠睾丸损伤的保护作用。糖尿病大鼠以 100 和 400 mg/kg 的剂量口服 SRE,持续 4 周。SRE 改善体重增加、睾丸重量、睾丸指数和增加血清睾酮浓度。此外,SRE 增加了睾丸抗氧化酶,包括超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶。此外,SRE 改善了睾丸炎症介质,如髓过氧化物酶、肿瘤坏死因子 α、白细胞介素 6、在治疗的糖尿病大鼠中,p38 MAPK 和核因子 kappa B 激活并减少睾丸细胞凋亡。在治疗糖尿病大鼠后,SRE 还提高了精子参数。总之,我们的结果表明,SRE 通过抑制氧化应激和炎症来改善糖尿病引起的睾丸损伤。
更新日期:2020-10-15
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