The International Journal of Biochemistry & Cell Biology ( IF 4 ) Pub Date : 2020-10-15 , DOI: 10.1016/j.biocel.2020.105864 Christopher D Pascoe 1 , Jignesh Vaghasiya 1 , Andrew J Halayko 1
Oxidative stress is an important feature of asthma pathophysiology that is not currently targeted by any of our frontline treatments. Reactive oxygen species, generated during times of heightened oxidative stress, can damage cellular lipids causing the production of oxidation specific epitopes (OSE). OSEs are elevated in chronic inflammatory diseases and promoting their clearance by the body, through pattern recognition receptors and IgM antibodies, prevents and resolves inflammation and tissue damage in animal models. Current research on OSEs in asthma is limited. Although they are present in the lungs of people with asthma during periods of exacerbation or allergen exposure, we do not know if they are linked with disease pathobiology. This article reviews our current understanding of OSEs in asthma and explores whether targeting OSE clearance mechanisms may be a novel therapeutic intervention for asthma.
中文翻译:
哮喘中的氧化特异性表位:治疗的新可能性
氧化应激是哮喘病理生理学的一个重要特征,目前我们的任何一线治疗均未针对该特征。在氧化应激加剧期间产生的活性氧物质会破坏细胞脂质,导致产生氧化特异性表位 (OSE)。OSE 在慢性炎症性疾病中升高,并通过模式识别受体和 IgM 抗体促进它们被身体清除,预防和解决动物模型中的炎症和组织损伤。目前对哮喘中 OSE 的研究是有限的。尽管它们在哮喘发作或接触过敏原期间存在于哮喘患者的肺部,但我们不知道它们是否与疾病病理生物学有关。