The study was devised to prepare berberine nanoparticles by anti-solvent precipitation method and were assessed for their hepatoprotective effect in Male Sprague-Dawley rats against carbon tetrachloride. The pharmacokinetic parameters of the prepared nanoparticles and berberine were evaluated in rabbits. Histopathological studies and blood biochemical analyses were carried out to evaluate the role of both forms of berberine in the experimental animals. Substantial improvement in the liver function test enzymes levels and liver histopathology were achieved in the animals treated with berberine nanoparticles in comparison to the unprocessed berberine whereas, pharmacokinetic parameters for nanoform of berberine were about 3.97 and 3.88 folds higher than that of the unprocessed berberine. The study revealed that the reduction of berberine particle size to nano range improved pharmacokinetic parameters in rabbits. The nano berberine provided better liver protection in experimental rats and high berberine blood concentration. Thus, better hepatoprotective and pharmacokinetics effects were observed for the nano form in comparison to unprocessed form.

该研究旨在通过反溶剂沉淀法制备小ber碱纳米颗粒，并评估其在雄性Sprague-Dawley大鼠中对四氯化碳的保肝作用。评价了所制备的纳米颗粒和小ber碱的药代动力学参数。进行了组织病理学研究和血液生化分析，以评估两种形式的小ber碱在实验动物中的作用。与未经加工的小ber碱相比，用黄连素纳米颗粒治疗的动物的肝功能测试酶水平和肝脏组织病理学得到了显着改善，而小form碱纳米形式的药代动力学参数比未加工的小碱高约3.97倍和3.88倍。研究表明，将小ber碱的粒径减小至纳米范围可改善家兔的药代动力学参数。纳米小ber碱可为实验大鼠提供更好的肝脏保护，并具有较高的小ber碱血浓度。因此，与未加工的形式相比，纳米形式观察到更好的肝保护和药代动力学作用。