Background

Circulating branched chain amino acids (BCAA) are associated with cardiometabolic risk, although the mechanisms leading to their accumulation remain uncertain. Examining the relationship between fasting status, metabolic syndrome, and type 2 diabetes (T2D) with circulating BCAA levels may provide insights into their metabolic handling.

Methods

We conducted cross-sectional analyses among 25,740 Women's Health Study participants (mean age 55 years).

Results

In multivariable linear regression models, fasting was associated with lower plasma BCAAs vs. non-fasting in women without metabolic syndrome or T2D (% mean difference = −5.1%; 95% CI = −5.8, −4.5) and among women with metabolic syndrome only (−3.7%; −4.9, −2.6), p_interaction = 0.002. However, there was no difference in BCAAs by fasting status among women with T2D (0.4%; −3.7, 4.7).

Conclusions

We observed higher BCAAs with worsening metabolic health status. Fasting is modestly associated with lower plasma BCAAs, except among women with T2D. These findings support hypotheses that impaired BCAA catabolism may be a feature of T2D pathophysiology.

中文翻译：

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与女性血浆支链氨基酸浓度相关的空腹状态和代谢健康

背景

循环支链氨基酸 (BCAA) 与心脏代谢风险相关，尽管导致其积累的机制仍不确定。检查禁食状态、代谢综合征和 2 型糖尿病 (T2D) 与循环 BCAA 水平之间的关系可能会提供对其代谢处理的见解。

方法

我们对 25,740 名女性健康研究参与者（平均年龄 55 岁）进行了横断面分析。

结果

在多变量线性回归模型中，在没有代谢综合征或 T2D 的女性（% 均值差 = -5.1%；95% CI = -5.8，-4.5）和代谢综合征女性中，禁食与血浆 BCAAs 与非禁食相关仅（-3.7%；-4.9，-2.6），p_交互作用 = 0.002。然而，T2D 女性的禁食状态对 BCAAs 没有差异（0.4%；-3.7, 4.7）。

结论

我们观察到更高的 BCAAs 与恶化的代谢健康状况。除 T2D 女性外，禁食与较低的血浆 BCAAs 适度相关。这些发现支持了 BCAA 分解代谢受损可能是 T2D 病理生理学特征的假设。