BACKGROUND The supplementary motor area (SMA) is involved in several aspects of motor control and its can be associated to a contralateral motor deficit and speech disorders. After the resection of low-grade gliomas, this syndrome is diffusely reported but it is rarely investigated in high-grade gliomas. SMA deficits may resolve completely or with minor sequelae within weeks. Whether this condition of transient deficit affects survival, was not previously investigated, and is not currently understood. OBJECTIVE The study aimed to perform an accurate investigation concerning the real clinical and prognostic impact of the postoperative SMA syndrome in order to shed light over its relationship to survival parameters and postoperative functional status of the patients. METHODS We performed a retrospective review of a series of 176 surgically treated patients suffering from Glioblastomas. Tumors classified as Group A: Involving the SMA and Group B: Lesion located outside and distal to the SMA but in anatomical relationship to primary motor cortices (PM1) or corticospinal tract (CST), in order to investigate differences concerning immunohistochemical and molecular profiles in regard to the survival parameters. RESULTS Although lesions involving SMA demonstrated a significantly higher volume in respect to their general counterparts they did not significantly differ in concerns to the molecular patterns, pre and postoperative KPS scores and in PFS and OS findings. CONCLUSIONS In our cohort SMA-syndrome is reversible and therefore guarantees a satisfactory functional status at follow-up, apparently not compromising survival when compared to other lesions affecting the primary or cortical motor area -spinal tract.

中文翻译：

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出现术后 SMA 综合征的 GBM 患者与涉及皮质脊髓束和初级运动皮层的 GBM 患者之间没有预后差异

背景辅助运动区(SMA) 涉及运动控制的多个方面，并且它可能与对侧运动缺陷和言语障碍有关。低级别胶质瘤切除后，这种综合征被广泛报道，但很少在高级别胶质瘤中进行研究。SMA 缺陷可能会在数周内完全消失或伴有轻微后​​遗症。这种暂时性缺陷状况是否会影响生存，以前没有研究过，目前也不了解。目的 本研究旨在对术后 SMA 综合征的真实临床和预后影响进行准确调查，以阐明其与患者生存参数和术后功能状态的关系。方法 我们对 176 名接受手术治疗的胶质母细胞瘤患者进行了回顾性研究。归类为 A 组的肿瘤：涉及 SMA 和 B 组：病变位于 SMA 的外部和远端，但与初级运动皮层 (PM1) 或皮质脊髓束 (CST) 具有解剖学关系，以研究有关免疫组织化学和分子特征的差异关于生存参数。结果 尽管涉及 SMA 的病变表现出明显高于一般病变的体积，但它们在分子模式、术前和术后 KPS 评分以及 PFS 和 OS 发现方面没有显着差异。结论 在我们的队列中，SMA 综合征是可逆的，因此在随访时保证了令人满意的功能状态，