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Distribution of genes encoding 16S rRNA methyltransferase in plazomicin-nonsusceptible carbapenemase-producing Enterobacterales in Brazil
Diagnostic Microbiology and Infectious Disease ( IF 2.9 ) Pub Date : 2020-10-15 , DOI: 10.1016/j.diagmicrobio.2020.115239
Larissa Bail 1 , Carmen Antonia Sanches Ito 1 , Lavinia Nery Villa Stangler Arend 2 , Marcelo Pilonetto 3 , Keite da Silva Nogueira 4 , Felipe Francisco Tuon 5
Affiliation  

Background: The presence of 16S rRNA methyltranferases (16S-RMTases) in carbapenemase-producing Enterobacterales (CPE) is a major concern because it inactivates all clinical use of aminoglycosides, including plazomicin. The aim of this study is to investigate the prevalence of 16S-RMTases in CPE nonsusceptible to plazomicin collected in different Brazilian hospitals. Methods: All isolates with plazomicin MIC ≥ 4 µg/mL (n = 67) were screened for the presence of 16S-RMTases by sequencing. Results: 54 (80.6%) isolates encoded 16S-RMTase genes (41 rmtB1, 7 armA, 3 rmtD2, 1 rmtD1 and 2 rmtC). Among 41 samples rmtB1 positive, 40 co-harbored blaKPC-2 and 1 blaOXA-48 gene. Of the seven isolates harboring armA gene, 6 were New Delhi Metallo-beta-lactamase (NDM)-producer. rmtD was only found in isolates Klebsiella pneumoniae Carbapenemase (KPC)-producers, one in Serratia marcescens with rmtD2, not reported in Brazil. Conclusion: The co-existence of 16S-RMTase and CPE is worrisome because of limited treatment options and the endemic characteristic of (KPC) and NDM in Brazil.



中文翻译:

在巴西产生吡唑米星的不敏感碳青霉烯酶的肠杆菌中编码16S rRNA甲基转移酶的基因的分布

背景:在产生碳青霉烯酶的肠杆菌(CPE)中存在16S rRNA甲基转移酶(16S-RMTase)是一个主要的问题,因为它会使包括吡唑米星在内的氨基糖苷类的所有临床用途失活。这项研究的目的是调查在巴西不同医院收集的吡唑米星不敏感的CPE中16S-RMTase的患病率。方法:通过测序,筛选出所有吡唑米星MIC≥4 µg / mL(n = 67)的分离株是否存在16S-RMTase。结果: 54(80.6%)分离株的编码16S-RMTase基因(41 rmtB1,7 ARMA,3 rmtD2,1 rmtD1和2 RMTC)。在41个样本中rmtB1阳性,40个共同携带的bla KPC-2和1 bla OXA-48基因。在具有armA基因的7个分离株中,有6个是新德里金属β-内酰胺酶(NDM)生产者。rmtD仅在肺炎克雷伯菌肺炎克雷伯菌酶(KPC)生产者中发现,该菌株在粘质沙雷氏菌中rmtD2,在巴西未见报道。结论:16S-RMTase和CPE的共存令人担忧,因为巴西的治疗选择有限以及(KPC)和NDM的地方性特征。

更新日期:2020-10-30
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