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Dynamic exchange of two types of stator units in Bacillus subtilis flagellar motor in response to environmental changes
Computational and Structural Biotechnology Journal ( IF 6 ) Pub Date : 2020-10-15 , DOI: 10.1016/j.csbj.2020.10.009
Naoya Terahara , Keiichi Namba , Tohru Minamino

Bacteria can migrate towards more suitable environments by rotating flagella that are under the control of sensory signal transduction networks. The bacterial flagellum is composed of the long helical filament functioning as a propeller, the flexible hook as a universal joint and the basal body as a rotary motor powered by ion motive force across the cell membrane. The flagellar motor consists of a rotor and multiple stator units, each of which couples the ion flow through its ion channel with force generation. The flagellar building blocks and motor proteins are highly conserved among bacterial species, but structural and functional diversity of flagella has also been revealed. It has been reported that the structure and function of the flagellar motor of a Gram-positive bacterium, Bacillus subtilis, differ from those of Escherichia coli and Salmonella. The flagellar motor of the B. subtilis BR151MA strain possesses two distinct types of stator complexes, H+-type MotAB and Na+-type MotPS, around the rotor. These two types of stator units dynamically assemble to and disassemble from the rotor in response to environmental changes such as viscosity and external Na+ concentrations. In this mini-review article, we describe our recent understanding of the structure and dynamics of the B. subtilis flagellar motor.



中文翻译:

枯草芽孢杆菌鞭毛马达中两种类型的定子单元根据环境变化动态交换

细菌可以通过旋转在感官信号转导网络控制下的鞭毛向更合适的环境迁移。细菌鞭毛由起螺旋桨作用的长螺旋状细丝,作为万向接头的挠性钩和由穿过细胞膜的离子动力提供动力的基体组成的旋转电动机组成。鞭毛马达由一个转子和多个定子单元组成,每个定子单元将通过其离子通道的离子流与力产生耦合。鞭毛构件和运动蛋白在细菌物种中高度保守,但鞭毛的结构和功能多样性也已被揭示。据报道,革兰氏阳性菌枯草芽孢杆菌鞭毛运动的结构和功能,不同于大肠杆菌沙门氏菌枯草芽孢杆菌BR151MA菌株的鞭毛马达在转子周围具有两种不同类型的定子复合体:H +型MotAB和Na +型MotPS。这两种类型的定子单元会根据环境变化(例如粘度和外部Na +浓度)动态地组装到转子上和从转子上拆卸下来。在这篇迷你评论文章中,我们描述了我们对枯草芽孢杆菌鞭毛马达的结构和动力学的最新了解。

更新日期:2020-10-16
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