The present short review covers a new class of bioactive fully functionalized calix[4]arenes representing symmetrical bolaform amphiphiles associated with two identical opposing polar regions separated by a lipophilic semi-cylindrical core. Bioactivities (anticancer, antituberculosis, anti-infective) of these cyclic tetramers are due to their special features including the multivalency, higher water-solubility, higher permeability to the cell membrane, and unique spatial pre-organization of terminal polar functional groups in the bola-topology.

中文翻译：

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Calixbas：Calix[4]Arene-Based Bioactive Bolaamphiphiles

本简短综述涵盖了一类新的生物活性全功能化杯 [4] 芳烃，它们代表对称的棒状两亲物，与两个相同的相反极性区域相关联，由亲脂性半圆柱形核心隔开。这些环状四聚体的生物活性（抗癌、抗结核、抗感染）是由于它们的特殊特性，包括多价性、更高的水溶性、更高的细胞膜渗透性以及博拉中末端极性官能团的独特空间预组织-拓扑。