A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

有限数量的外围目标会产生疼痛。炎症介质可以使这些物质变得敏感。该综述涉及专门或主要作用于感觉神经元的靶标、参与针对感觉神经元的炎症的介质以及参与更一般炎症过程的介质，其中可以预期继发于抗炎作用的镇痛作用。讨论了处理这些系统的不同方法，包括清除促炎介质、应用抗炎介质以及抑制促炎或促进抗炎受体。新方法与现有方法形成对比；提到了目前的进展阶段，特别是考虑到是否有来自分子和细胞水平、来自动物或人体试验的数据，包括市场发布后的早期阶段。概述了出版活动，考虑到 IuPhar/BPS 策划的目标列表，仅限于与疼痛相关的出版物，该列表也用于确定主题。