Longer time to diagnosis for patients with eosinophilic esophagitis can lead to adverse patient outcomes, but the length of diagnostic delay has not been quantified for patients with eosinophilic esophagitis in Canada. Our study defines the time to diagnosis (TTD) for pediatric patients with eosinophilic esophagitis in British Columbia and identifies factors that predict increased time to diagnosis. The median TTD was 21 months (1.75 years; IQR = 7, 45) with a median age at EoE diagnosis of 105 months (8.75 years; IQR = 44, 156). Caucasians experienced significantly longer TTD compared to other ethnicities (24 months (IQR = 7, 52) and 12 months (IQR = 4.5, 23) respectively, p = 0.008). Caucasian ethnicity (p = 0.037) and older age at the time of diagnosis (p = 0.006) predicted increased TTD. Our model explained 7.9% (Adjusted R2 = 0.079) of the total variance for our cohort.

中文翻译：

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为了缩短诊断时间：不列颠哥伦比亚省的小儿嗜酸性食管炎

嗜酸性粒细胞性食管炎患者的诊断时间较长会导致不良的患者预后，但加拿大的嗜酸性粒细胞性食管炎患者的诊断延迟时间尚未确定。我们的研究确定了不列颠哥伦比亚省嗜酸性粒细胞性食管炎的小儿诊断时间（TTD），并确定了预测诊断时间增加的因素。TTD的中位数为21个月（1.75年； IQR = 7、45），EoE诊断时的中位年龄为105个月（8.75年； IQR = 44,156）。与其他种族（分别为24个月（IQR = 7、52）和12个月（IQR = 4.5、23）相比，高加索人的TTD明显更长）（p = 0.008）。白人（p = 0.037）和诊断时年龄较大（p = 0.006）预计TTD会增加。我们的模型解释了7.9％（调整后的R2 = 0。