This study spots light on combined Wound healing process conjoining blood coagulation, inflammation reduction, proliferation and remodeling of the cells. The objective is to overcome the drawbacks of conventional clinically applied wound dressings such as poor rigidity, porosity, mechanical potency and bactericidal activity. As nosocomial infection is a very common condition at the wound site, bio-adhesive materials with intrinsic antibacterial properties are used in clinical applications. Considering the provenability of Wollastonite [Calcium silicate (CaSiO3)] to regenerate the soft tissues by inducing vascularization and regeneration of fibroblast cells And the antibacterial potentiality of zinc in clinical applications, the present study focuses on synthesis of Zn-Ws particles and evaluation of its antimicrobial and wound healing potentialities towards skin tissue engineering applications. The compositional characterization by EDAS and FT-IR spectral analysis have substantiated the presence of major elements and corresponding band stretching associated with the synthesized particles whereas the particles morphology by SEM images have shown the size of the Ws and Zn-Ws to be 370 nm and 530 nm respectively. From the in vitro studies, skin regenerative potential of Zn-Ws was determined on promoting fibroblast cell (NIH3T3) proliferation by providing better adhesiveness, biocompatibility and cytocompatibility. The antibacterial property of Zn-Ws evaluation by minimum inhibitory concentration (MIC) and zone of inhibition (ZOI) methods against clinical isolates of Gram +Ve and Gram –Ve bacterial strains have confirmed that the addition of Zn has diminished the bacterial growth and also helped in degrading the bacterial biofilms. Thus it is summed up that the process of wound healing is expected to occur with reduced risk of post-injury infections by the presence of zinc-doping on wollastonite for skin tissue application.

这项研究揭示了结合血液凝固、炎症减轻、增殖和细胞重塑的联合伤口愈合过程。目的是克服常规临床应用伤口敷料的缺点，例如刚性差、多孔性、机械效力和杀菌活性差。由于医院感染是伤口部位非常常见的情况，因此在临床应用中使用具有内在抗菌特性的生物粘附材料。考虑到硅灰石 [硅酸钙 (CaSiO3)] 通过诱导成纤维细胞的血管化和再生来再生软组织以及锌在临床应用中的抗菌潜力，本研究的重点是 Zn-Ws 颗粒的合成以及评估其在皮肤组织工程应用中的抗菌和伤口愈合潜力。EDAS 和 FT-IR 光谱分析的成分表征证实了与合成颗粒相关的主要元素的存在和相应的带拉伸，而 SEM 图像的颗粒形态显示 Ws 和 Zn-Ws 的尺寸为 370 nm 和分别为 530 纳米。来自 EDAS 和 FT-IR 光谱分析的成分表征证实了与合成颗粒相关的主要元素的存在和相应的带拉伸，而 SEM 图像的颗粒形态显示 Ws 和 Zn-Ws 的尺寸为 370 nm 和分别为 530 纳米。来自 EDAS 和 FT-IR 光谱分析的成分表征证实了与合成颗粒相关的主要元素的存在和相应的带拉伸，而 SEM 图像的颗粒形态显示 Ws 和 Zn-Ws 的尺寸为 370 nm 和分别为 530 纳米。来自在体外研究中，通过提供更好的粘附性、生物相容性和细胞相容性，确定了 Zn-Ws 在促进成纤维细胞 (NIH3T3) 增殖方面的皮肤再生潜力。通过最小抑菌浓度 (MIC) 和抑菌圈 (ZOI) 方法评估 Zn-Ws 对革兰氏+Ve 和革兰氏-Ve 菌株的临床分离株的抗菌性能证实，添加 Zn 减少了细菌的生长，并且还有助于降解细菌生物膜。因此，总结出通过在硅灰石上掺杂锌用于皮肤组织应用，预计伤口愈合过程会降低受伤后感染的风险。