Background: In India, multidrug resistance in community and hospital associated Gram-negative pathogens has increased sharply over the past few years. In the absence of novel oral multidrug resistant-pathogen active therapies, the therapeutic situation with regard to community infections is even more challenging. Hence, the focus is now shifting toward potentially expanding the utility of older antibiotics such as fosfomycin and nitrofurantoin beyond their approved pathogen coverage. The current study was undertaken to assess the activity of fosfomycin and nitrofurantoin against Enterobacterales pathogens through minimum inhibitory concentration (MIC) determination to facilitate monitoring future shifts in susceptibility to these agents.

中文翻译：

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磷霉素和呋喃妥因对印度三级医院分离的现代肠杆菌病原体的体外活性

背景：在印度，社区和医院相关革兰氏阴性病原体的多重耐药性在过去几年中急剧增加。在缺乏新型口服多重耐药病原体活性疗法的情况下，社区感染的治疗情况更具挑战性。因此，现在的重点正在转向潜在地扩大旧抗生素（如磷霉素和呋喃妥因）的效用，超出其批准的病原体覆盖范围。目前的研究旨在通过最低抑菌浓度 (MIC) 测定来评估磷霉素和呋喃妥因对肠杆菌病原体的活性，以促进监测未来对这些药物的敏感性变化。