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Noninvasive Biomarkers of Gut Barrier Function in Patients Suffering from Diarrhea Predominant-IBS: An Update
Disease Markers ( IF 3.464 ) Pub Date : 2020-10-14 , DOI: 10.1155/2020/2886268
Michele Linsalata 1 , Giuseppe Riezzo 1 , Caterina Clemente 1 , Benedetta D'Attoma 1 , Francesco Russo 1
Affiliation  

The intestinal barrier plays a crucial role in the absorption of nutrients and in preventing the entry of pathogenic microorganisms and toxic molecules. Several studies have shown a compromised intestinal barrier associated with low-grade inflammation in the small intestinal mucosa in celiac disease, inflammatory bowel disease, and irritable bowel syndrome (IBS), particularly in IBS with diarrhea (IBS-D). In light of these new data, IBS is no longer considered a functional disease but rather a heterogeneous syndrome that has yet to be carefully studied. Therefore, investigating the integrity and function of the intestinal barrier is now essential to improving knowledge of the pathophysiology of IBS-D and to improving the management of IBS-D patients. However, the study of the intestinal barrier must clarify some still unsolved methodological aspects and propose standardised assays before becoming a useful diagnostic tool. In this framework, this review will discuss data about the tests that noninvasively evaluate the integrity and functionality of the human intestinal barrier, paying particular attention to patients with IBS-D, in both clinical and research situations.

中文翻译:

腹泻型 IBS 患者肠道屏障功能的无创生物标志物:更新

肠道屏障在营养吸收和防止病原微生物和有毒分子进入方面起着至关重要的作用。几项研究表明,肠道屏障受损与乳糜泻、炎症性肠病和肠易激综合征 (IBS) 中小肠粘膜的低度炎症相关,特别是在伴有腹泻的 IBS (IBS-D) 中。根据这些新数据,IBS 不再被视为一种功能性疾病,而是一种尚未仔细研究的异质综合征。因此,研究肠道屏障的完整性和功能现在对于提高对 IBS-D 病理生理学的了解和改善 IBS-D 患者的管理至关重要。然而,肠道屏障的研究必须澄清一些尚未解决的方法学问题,并在成为有用的诊断工具之前提出标准化检测方法。在这个框架中,本综述将讨论有关无创评估人类肠道屏障完整性和功能的测试的数据,特别关注临床和研究情况下的 IBS-D 患者。
更新日期:2020-10-14
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