Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also covalently modify target proteins. To date, less is known about UBLs than Ub and even less is known about the UBL called ubiquitin-fold modifier 1 (UFM1). Currently, our understanding of protein modification by UFM1 (UFMylation) is like a jigsaw puzzle with many missing pieces, and in some cases it is not even clear whether these pieces of data are in the right place. Here we review the current data on UFM1 from structural biology to biochemistry and cell biology. We believe that the physiological significance of protein modification by UFM1 is currently underestimated and there is more to it than meets the eye.

中文翻译：

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解密 UFMylation：如何用 UFM1 修饰蛋白质

除了泛素 (Ub) 之外，人类还有一组泛素样蛋白 (UBL)，它们也可以共价修饰靶蛋白。迄今为止，对 UBLs 的了解比 Ub 少，对称为泛素折叠修饰符 1 (UFM1) 的 UBL 了解得更少。目前，我们对UFM1（UFMylation）的蛋白质修饰的理解就像一个拼图，有很多缺失的部分，在某些情况下甚至不清楚这些数据是否在正确的位置。在这里，我们回顾了从结构生物学到生物化学和细胞生物学的 UFM1 的当前数据。我们认为，UFM1 修饰蛋白质的生理意义目前被低估了，它的意义远不止表面上的。