Impetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria Staphylococcus aureus and/or Streptococcus pyogenes. Antibiotic treatments, often topical, are used as the first-line therapy for impetigo. The efficacy of potential new antimicrobial compounds is first tested in in vitro studies and, if effective, followed by in vivo studies using animal models and/or humans. Animal models are critical means for investigating potential therapeutics and characterizing their safety profile prior to human trials. Although several reviews of animal models for skin infections have been published, there is a lack of a comprehensive review of animal models simulating impetigo for the selection of therapeutic drug candidates. This review critically examines the existing animal models for impetigo and their feasibility for testing the in vivo efficacy of topical treatments for impetigo and other superficial bacterial skin infections.

中文翻译：

---

脓疱疮动物模型：研究药物候选者的治疗评估的可行性和临床实用性的回顾。

脓疱病（学校疮）是儿童中常见的浅表皮肤感染，由革兰氏阳性菌金黄色葡萄球菌和/或化脓性链球菌引起。抗生素治疗，通常是局部治疗，被用作脓疱疮的一线治疗。潜在的新型抗菌化合物的功效首先在体外研究中进行测试，如果有效，则随后使用动物模型和/或人类进行体内研究。动物模型是在人体试验之前研究潜在疗法并表征其安全性的关键手段。尽管已经发表了几种针对皮肤感染的动物模型的综述，但是对于用于选择治疗药物候选物的模拟脓疱病的动物模型缺乏全面的综述。这篇评论严格审查了脓疱疮的现有动物模型及其在局部治疗脓疱疮和其他浅表细菌皮肤感染的体内治疗试验中的可行性。