Native to the Asia-Pacific region and widely applied in traditional Chinese medicine, the genus Daphniphyllum has produced over 330 known Daphniphyllum alkaloids. Investigations into these alkaloids have shown an exceptional range of interesting bioactivities. Challenging and caged polycyclic architectures and the promising biological profiles make Daphniphyllum alkaloids intriguing synthetic targets. Based on their backbones, these alkaloids can be categorized into 13–35 structurally distinct subfamilies. In addition to our work, almost 30 impressive total syntheses of Daphniphyllum alkaloids from seven subfamilies, namely, daphniphylline-type, secodaphniphylline-type, daphnilactone A-type, bukittinggine-type, daphmanidin A-type, calyciphylline A-type, and calyciphylline B-type alkaloids, have been reported by 11 research groups. However, many Daphniphyllum alkaloid subfamilies remain inaccessible by chemical synthesis.

中文翻译：

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茶花生物碱的全合成：从自行车到多样化的笼状结构。

水飞Da属原产于亚太地区，在中药中得到广泛应用，已生产了330多种已知的水飞Da生物碱。对这些生物碱的研究显示出范围广泛的有趣生物活性。具有挑战性的笼状多环结构和有前途的生物学特征使水蚤生物碱吸引了合成靶标。根据它们的骨架，这些生物碱可分为13–35个结构不同的亚家族。除我们的工作外，水杉共有近30种令人印象深刻的合成方法11个研究小组已经报告了7个亚家族的生物碱，它们分别是茶碱型，仲碱型，茶碱内酯A型，武吉丁嗪型，水飞蓟素A型，茶碱A型和茶碱B型。但是，许多水蚤生物碱亚科仍然无法通过化学合成获得。