Doxorubicin (DOX) is a very effective broad‐spectrum anticancer drug, yet its clinical application is badly restricted due to its serious side effects. Citronellal (CT), a specialized metabolite of plants found in Cymbopogon spp., is proved to exhibit many beneficial properties. In the current study, we intended to investigate the effect of CT on DOX‐induced hepatotoxicity in rats. Rats were treated with CT (200 mg/kg b.w./day orally), and given DOX (2.5 mg/kg b.w./week, intraperitoneally) to induce hepatotoxicity for six consecutive weeks. The results showed that CT administration could attenuate the DOX‐induced pathological changes of liver tissues and ameliorated the inappropriate alteration of liver function biomarkers (serum glutamic aspartate aminotransferase, glutamic pyruvic transaminase, and albumin) in serum and oxidative stress parameters (malondialdehyde, superoxide dismutase, and reduced glutathione) in the liver. Moreover, CT mitigated the Bax/Bcl‐2 ratio and caspase‐3 expression to inhibit cell apoptosis. Further study indicated that CT therapy could enhance the protein levels of p‐PI3K, p‐Akt, and CD31 in the liver. These results demonstrate that CT can ameliorate DOX‐induced hepatotoxicity in rats mediated by antioxidative stress, antiapoptosis, and proangiogenesis.

中文翻译：

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香茅醛通过抗氧化应激，抗凋亡和大鼠血管新生改善阿霉素诱导的肝毒性

阿霉素（DOX）是一种非常有效的广谱抗癌药物，但是由于其严重的副作用，其临床应用受到严格限制。香茅醛（CT），一种在ym柏中发现的植物的专门代谢产物被证明具有许多有益的特性。在本研究中，我们打算研究CT对DOX诱导的大鼠肝毒性的影响。大鼠接受CT（200 mg / kg bw /天，口服）治疗，并给予DOX（2.5 mg / kg bw /周，腹膜内）连续六周诱导肝毒性。结果表明，CT给药可以减轻DOX诱导的肝组织病理变化，并改善血清和氧化应激参数（丙二醛，超氧化物歧化酶）中肝功能生物标志物（血清谷氨酸天冬氨酸转氨酶，谷氨酸丙酮酸转氨酶和白蛋白）的不适当地改变。 ，并减少肝脏中的谷胱甘肽）。此外，CT减轻了Bax / Bcl-2比和caspase-3表达，从而抑制了细胞凋亡。进一步的研究表明，CT治疗可以提高肝脏中p-PI3K，p-Akt和CD31的蛋白水平。这些结果表明，CT可以改善DOX诱导的大鼠抗氧化应激，抗凋亡和促血管生成的肝毒性。