The brain's ability to act as an input filter and to suppress actions is crucial to navigate everyday life and impairments in these abilities affect quality of life substantially. Although Parkinson's disease (PD) is primarily known as a movement disorder, recent research has redefined it as a multisystem disorder affecting cognition, in particular inhibitory control and attentional resource allocation. Analysing the neural mechanisms underlying this cognitive deficit provides a better understanding of brain changes observed in patients affected by PD. Therefore, this study aimed to identify resource allocation to relevant and irrelevant stimuli in patients affected by PD. Besides neuropsychological tests, we employed electroencephalographic recordings during an auditory oddball paradigm in 13 patients suffering from idiopathic PD and 11 healthy controls (HC). Participants were instructed to ignore the standard stimulus and to respond as fast as possible to the rarely presented target tone. Event‐related potentials (ERP) and time‐frequency representations (TFR) were analyzed. Patients affected by PD showed faster response latencies to the task‐irrelevant standard tones, but slower response latencies to target tones compared to HC. This observation was prominent at frontal sites during later P3‐like processing stages. Reaction time, however, was prolonged in patients with PD, suggesting inefficient resource allocation. Additionally, TFR revealed reduced parietal alpha activity, which is associated with distractor suppression and functional inhibition in patients with PD compared to healthy controls. Thus, our results point towards inefficient resource allocation in patients with PD possibly driven by less functional inhibition through parietal alpha activity.

中文翻译：

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资源分配效率低下与帕金森氏病患者壁区α活性降低有关

大脑充当输入过滤器和抑制动作的能力对于导航日常生活至关重要，而这些能力的损害会严重影响生活质量。尽管帕金森氏病（PD）主要被称为运动障碍，但最近的研究将其重新定义为影响认知的多系统障碍，尤其是抑制控制和注意力资源分配。分析这种认知缺陷背后的神经机制，可以更好地了解受PD影响的患者的大脑变化。因此，本研究旨在确定资源分配给受PD影响的患者的相关和不相关刺激。除了神经心理测验 我们在13名患有特发性PD的患者和11名健康对照（HC）的听觉怪胎范例中采用了脑电图记录。指示参与者忽略标准刺激，并尽可能快地响应很少出现的目标音调。分析了事件相关电位（ERP）和时间频率表示（TFR）。与HC相比，受PD影响的患者对与任务无关的标准音调的反应潜伏期较快，但对目标音调的反应潜伏期较慢。在后期的P3类加工阶段，这一观察在额叶部位尤为突出。然而，PD患者的反应时间延长，提示资源分配效率低下。此外，TFR显示壁上α活性降低，与健康对照组相比，这与PD患者的干扰物抑制和功能抑制有关。因此，我们的研究结果表明，PD患者的资源分配效率低下，可能是由于顶叶α活性降低了功能抑制所致。