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Effect of Helicanthes elasticus (Desv.) Danser extracts on immune profile of Wistar albino rats
Saudi Journal of Biological Sciences ( IF 4.4 ) Pub Date : 2020-09-06 , DOI: 10.1016/j.sjbs.2020.08.049
K N Sunil Kumar 1 , G Dayanand Reddy 1 , Ravi Mundugaru 2 , Rajakrishnan Rajagopal 3 , Ahmed Alfarhan 3 , Young Ock Kim 4 , Sae Won Na 5 , Hak-Jae Kim 4
Affiliation  

Helicanthes elasticus (Desv.) Danser is a common type of mistletoes of Indian origin. In Indian traditional and folklore medicines the plant is claimed to possess a range of medicinal values such as immunomodulator, anti-diabetic and anti-microbial properties. However, there is no experimental proof for its therapeutic claim. The aqueous and alcoholic extracts of H. elastica were evaluated for its immuno-modulatory effect on antibody formation against sheep red blood cells and on cell mediated immunity of immunological paw edema model. Ethanolic and aqueous extracts have shown dose dependent elevation in the antibody titer value in comparison to control group at 14th and 21st day of sensitization (**p < 0.01). There is a mild to moderate elevation were observed in the immunological paw edema at highest dose (400 mg/kg) during 21st day after sensitization. The histopathological observation shows that there is an increase in the white pulp of spleen and increased cellularity and formation of distinct germinal cells in lymph node. H. elasticus extracts possess marked antibody formation propensity without significant modification on cell mediated immunity.



中文翻译:

弹力菊花 (Desv.) Danser 提取物对 Wistar 白化大鼠免疫特征的影响

Helicanthes elasticus (Desv.) Danser 是一种常见的槲寄生,原产于印度。在印度传统和民间传说药物中,该植物据称具有一系列药用价值,例如免疫调节剂、抗糖尿病和抗微生物特性。然而,没有实验证据证明其治疗作用。评估了弹性羊水和酒精提取物对针对绵羊红细胞的抗体形成和免疫性爪水肿模型的细胞介导的免疫的免疫调节作用。与致敏第 14 天和第 21 天的对照组相比,乙醇和水提取物显示出抗体效价值的剂量依赖性升高(**p < 0.01)。致敏后第 21 天,最高剂量(400 mg/kg)观察到免疫性爪水肿轻度至中度升高。组织病理学观察显示,脾白髓增大,淋巴结细胞增多,形成明显的生发细胞。H. elasticus提取物具有显着的抗体形成倾向,且不会显着改变细胞介导的免疫。

更新日期:2020-10-14
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