Background

Inflammation occurs after acute ischemic stroke (AIS), and complement C1q is involved in inflammation. However, studies about the association of complement C1q with AIS are still rare. The aim of our study is to investigate the relationship between serum C1q concentration and the clinical severity of AIS. Methods: A total of 1294 patients were enrolled in our study, including 647 patients with AIS and 647 non-stroke controls. The infarction volume of AIS was assessed by the diameter of maximum transverse section (DMTS) based on diffusion-weighted imaging (DWI) of brain magnetic resonance imaging. Neurological impairment was assessed by the National Institute of Health Stroke Scale (NIHSS). The association of serum C1q levels with DMTS or NIHSS was investigated by Pearson's or Spearman's correlation analysis. Results: Serum C1q levels of patients with AIS were significantly higher than those of individuals without AIS. Serum levels of C1q were associated with DMTS (r=0.511, p<0.001) and NIHSS (r=0.433, p<0.001) among patients with AIS. Conclusion: Serum C1q concentration was positively associated with DMTS and NIHSS of patients with AIS.

中文翻译：

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急性缺血性卒中患者血清补体C1q浓度与神经功能障碍严重程度和梗死面积的关系

背景

急性缺血性中风（AIS）后发生炎症，补体C1q参与炎症。然而，关于补体C1q与AIS的关联的研究仍然很少。我们研究的目的是研究血清C1q浓度与AIS临床严重程度之间的关系。方法：本研究共纳入1294例患者，包括647例AIS患者和647例非卒中对照。根据脑磁共振成像的弥散加权成像（DWI），通过最大横截面直径（DMTS）评估AIS的梗死体积。神经损伤由美国国立卫生研究院卒中量表（NIHSS）评估。通过皮尔森或斯皮尔曼相关分析研究了血清C1q水平与DMTS或NIHSS的相关性。结果：AIS患者的血清C1q水平显着高于无AIS患者的血清C1q水平。在AIS患者中，血清C1q水平与DMTS（r = 0.511，p <0.001）和NIHSS（r = 0.433，p <0.001）相关。结论：AIS患者血清C1q水平与DMTS和NIHSS呈正相关。