The C-X-C motif (CXC) chemokines play an important role in inflammatory processes and angiogenesis and are also associated with tumor development, progression and metastasis. They can be either promoting or inhibiting factors in colorectal cancers (CRC). The expression patterns and prognostic values of the CXC family still need further investigation. In this study, we investigated data related to transcription, translation, survival and tumor immune infiltration for CXC chemokines in patients with CRC from the ONCOMINE, GEPIA, cBioPortal, HPA and TIMER databases. We found that the expression levels of CXCL1-3, CXCL5, and CXCL8 were higher in CRC tissues than in colorectal tissues. Expression among stages significantly varied for CXCL1-3 and CXCL9-11. The survival analysis revealed that high transcriptional levels of CXCL4 and CXCL9-11 could serve as positive prognostic factors for patients with CRC. CXCL9-11 were highly associated with CD8+ T cells and natural killer (NK) cells in the tumor immune infiltration analysis, indicating their role in the antitumor immune response. This study implies that CXCL1-3, CXCL5, and CXCL8 are important factors during CRC oncogenesis and that CXCL9-11 could be new biomarkers for the prognosis of CRC.

CXC基序（CXC）趋化因子在炎症过程和血管生成中起重要作用，并且还与肿瘤的发生，发展和转移有关。它们可以是结直肠癌（CRC）的促进因子或抑制因子。CXC家族的表达模式和预后价值仍有待进一步研究。在这项研究中，我们从ONCOMINE，GEPIA，cBioPortal，HPA和TIMER数据库中调查了CRC患者CXC趋化因子的转录，翻译，存活和肿瘤免疫浸润的相关数据。我们发现CRC组织中CXCL1-3，CXCL5和CXCL8的表达水平高于结直肠组织。对于CXCL1-3和CXCL9-11，各阶段之间的表达差异显着。生存分析表明，CXCL4和CXCL9-11的高转录水平可作为CRC患者的阳性预后因素。在肿瘤免疫浸润分析中，CXCL9-11与CD8 + T细胞和自然杀伤（NK）细胞高度相关，表明它们在抗肿瘤免疫反应中的作用。这项研究表明，CXCL1-3，CXCL5和CXCL8是CRC致癌过程中的重要因素，而CXCL9-11可能是CRC预后的新生物标记。