当前位置: X-MOL 学术Clin. Neurophysiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of depth electrode montage and single-pulse electrical stimulation sites on neuronal responses and effective connectivity
Clinical Neurophysiology ( IF 4.7 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.clinph.2020.09.010
Takumi Mitsuhashi 1 , Masaki Sonoda 2 , Hirotaka Iwaki 3 , Aimee F Luat 4 , Sandeep Sood 5 , Eishi Asano 6
Affiliation  

OBJECTIVE To determine the optimal depth electrode montages for the assessment of effective connectivity based on single-pulse electrical stimulation (SPES). To determine the effect of SPES locations on the extent of resulting neuronal propagations. METHODS We studied 14 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of cortico-cortical evoked potentials (CCEPs) and cortico-cortical spectral responses (CCSRs). We determined the effects of electrode montage and stimulus sites on the CCEP/CCSR amplitudes. RESULTS Bipolar and Laplacian montages effectively reduced the degree of SPES-related signal deflections at extra-cortical levels, including outside the brain, while maintaining those at the cortical level. SPES of structures more proximal to the deep white matter, compared to the cortical surface, elicited greater CCEPs and CCSRs. CONCLUSIONS On depth electrode recording, bipolar and Laplacian montages are suitable for measurement of near-field CCEPs and CCSRs. SPES of the white matter axons may induce neuronal propagations to extensive regions of the cerebral cortex. SIGNIFICANCE This study helps to establish the practical guidelines on the diagnostic use of CCEPs/CCSRs.

中文翻译:

深度电极蒙太奇和单脉冲电刺激部位对神经元反应和有效连接的影响

目的 确定基于单脉冲电刺激 (SPES) 的有效连通性评估的最佳深度电极蒙太奇。确定 SPES 位置对产生的神经元传播程度的影响。方法 我们研究了 14 名接受深度电极侵入性监测并测量皮质-皮质诱发电位 (CCEP) 和皮质-皮质光谱反应 (CCSR) 的癫痫患者。我们确定了电极蒙太奇和刺激部位对 CCEP/CCSR 振幅的影响。结果双极和拉普拉斯蒙太奇有效地降低了皮层外水平(包括大脑外)的 SPES 相关信号偏转程度,同时保持皮层水平的信号偏转。与皮质表面相比,更靠近深部白质的结构的 SPES,引发了更大的 CCEP 和 CCSR。结论 在深度电极记录中,双极和拉普拉斯蒙太奇适用于测量近场 CCEP 和 CCSR。白质轴突的 SPES 可能会诱导神经元传播到大脑皮层的广泛区域。意义 本研究有助于建立关于 CCEPs/CCSRs 诊断使用的实用指南。
更新日期:2020-12-01
down
wechat
bug