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Microfluidic synthesis of thermo-responsive block copolymer nano-objects via RAFT polymerization
Journal of Polymer Research ( IF 2.8 ) Pub Date : 2020-10-14 , DOI: 10.1007/s10965-020-02290-3
Tomke E. Glier , Mohammad Vakili , Martin Trebbin

Continuous flow microreactors offer advantages such as quick heat dissipation, high throughput as well as reproducible and flexible product quality. Here we present a X-ray compatible microfluidic reaction vessel suitable for studying living polymerization reactions in flow under oxygen-free conditions. Diblock copolymer nano-objects were synthesized via mixing-induced reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization in a microfluidic channel. A water-soluble macro chain transfer agent was chain-extended with N-isopropylacrylamide (NIPAm). Poly(NIPAm) is a thermo-responsive polymer with a lower critical solution temperature of 32 °C. Thus, heating the polymer solution results in the formation of micelles according to the polymerization-induced thermal self-assembly route. To implement the reaction in a microfluidic sample environment, metal-polyimide devices have been fabricated. The use of microfluidics for the synthesis of copolymers enhanced the control of reaction parameters. Moreover, the use of X-ray compatible materials paves the way for future in situ time-resolved structural studies of the flowing species.



中文翻译:

通过RAFT聚合微流体合成热响应性嵌段共聚物纳米物体

连续流微反应器具有诸如快速散热,高通量以及可重现和灵活的产品质量等优点。在这里,我们介绍了一种X射线兼容的微流体反应容器,适用于研究在无氧条件下流动中的活性聚合反应。通过在微流体通道中混合诱导的可逆加成-断裂链转移(RAFT)水分散聚合反应合成了二嵌段共聚物纳米物体。水溶性大链转移剂用N扩链-异丙基丙烯酰胺(NIPAm)。聚(NIPAm)是一种热响应性聚合物,其临界溶液温度较低,为32°C。因此,根据聚合引发的热自组装路线,加热聚合物溶液导致形成胶束。为了在微流体样品环境中进行反应,已经制造了金属-聚酰亚胺装置。将微流体用于共聚物的合成增强了反应参数的控制。此外,使用X射线兼容材料为流动物种的未来原位时间分辨结构研究铺平了道路。

更新日期:2020-10-14
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