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Cationic drugs and COVID-19
International Journal of Immunopathology and Pharmacology ( IF 3.5 ) Pub Date : 2020-10-13 , DOI: 10.1177/2058738420966078
Oreste Vittore Brenna 1, 2 , Sara Torretta 3, 4 , Lorenzo Pignataro 3, 4 , Federica Di Berardino 3, 4
Affiliation  

Given the sharp spreading of COVID-19 pandemic all around the world, our attention was brought to consider that that many cationic drugs (i.e. those characterized by the presence, at physiological pH value, of one or more cationic groups, both primary, secondary, tertiary and guanidinic aminic groups) could have any effect in impairing SARS-CoV2 entry in the host cell. This could open to new therapeutic chances against COVID-19.



中文翻译:

阳离子药物和COVID-19

鉴于COVID-19大流行病在世界范围内的急剧扩散,我们的注意力被认为是许多阳离子药物(即以生理pH值存在的一个或多个阳离子基团,包括伯,仲,叔胺基团和胍基胺基团可能对削弱SARS-CoV2进入宿主细胞有任何影响。这可能为抗COVID-19带来新的治疗机会。

更新日期:2020-10-13
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