The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting the mTOR pathway is a promising strategy to fight against certain human diseases.

中文翻译：

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代谢和癌症中的mTOR信号传导

雷帕霉素（mTOR）的机械/哺乳动物靶标是一种丝氨酸/苏氨酸激酶，是人类生理活动的主要调节剂。失调的mTOR信号传导涉及多种疾病，例如癌症，肥胖症，糖尿病和神经退行性疾病。在本期特刊上发表的论文总结了对mTOR途径及其在调节组织再生，调节T细胞分化和功能以及各种类型的癌症（包括血液系统恶性肿瘤，皮肤癌，前列腺癌，乳腺癌和头颅癌）中的作用的最新了解。颈部癌。研究结果突出表明，靶向mTOR途径是对抗某些人类疾病的有前途的策略。