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Progress in Electrochemical Trifluoromethylation Reactions
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2020-10-12 , DOI: 10.1002/adsc.202000996
Rasmi P. Bhaskaran 1 , Beneesh P. Babu 1
Affiliation  

The importance of fluorinated organic molecules in drugs and pharmaceuticals led to the development of several synthetic methods for introducing fluorine into bioactive molecules and trifluoromethylation is one of the key approaches for the same. Electrochemical organic synthesis has emerged as one of the most sustainable, green synthetic strategies in recent years and new developments in electroorganic synthesis also focus on electrochemical trifluoromethylation of organic compounds. A considerable number of reports have appeared in recent literature and this review surveys all the recent developments in electrochemical trifluoromethylation reactions. This highly sustainable trifluoromethylating protocol will emerge further soon and pave the way for more energy‐efficient and green protocols.

中文翻译:

电化学三氟甲基化反应的研究进展

氟化有机分子在药物和药物中的重要性导致开发了几种将氟引入生物活性分子的合成方法,而三氟甲基化是其关键方法之一。近年来,电化学有机合成已成为最可持续的绿色合成策略之一,并且有机合成的新进展也集中在有机化合物的电化学三氟甲基化上。在最近的文献中已经出现了大量的报告,并且该综述调查了电化学三氟甲基化反应的所有最新进展。这种高度可持续的三氟甲基化方案将很快出现,为更节能和绿色的方案铺平道路。
更新日期:2020-12-08
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